Thiourea-catalyzed enantioselective cyanosilylation of ketones.

ABSTRACT: The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones. The hindered tertiary amine substituent plays a crucial role with regard to both stereoinduction and reactivity, suggesting a cooperative mechanism involving electrophile activation by thiourea and nucleophile activation by the amine.

SUBMITTER: Fuerst DE 

PROVIDER: S-EPMC3166885 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature