A powerful approach for association analysis incorporating imprinting effects.

ABSTRACT:

Motivation

For a diallelic marker locus, the transmission disequilibrium test (TDT) is a simple and powerful design for genetic studies. The TDT was originally proposed for use in families with both parents available (complete nuclear families) and has further been extended to 1-TDT for use in families with only one of the parents available (incomplete nuclear families). Currently, the increasing interest of the influence of parental imprinting on heritability indicates the importance of incorporating imprinting effects into the mapping of association variants.

Results

In this article, we extend the TDT-type statistics to incorporate imprinting effects and develop a series of new test statistics in a general two-stage framework for association studies. Our test statistics en

SUBMITTER: Xia F 

PROVIDER: S-EPMC3167056 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature