MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes.

ABSTRACT:

Rationale

Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood.

Objective

Given the potential of microRNAs (miRNAs) to influence large gene networks and modify complex developmental and disease phenotypes, we searched for miRNAs that were regulated during the postnatal switch to terminal differentiation.

Methods and results

Microarray analysis revealed subsets of miRNAs that were upregulated or downregulated in cardiac ventricles from mice at 1 and 10 days of age (P1 and P10). Interestingly, miR-195 (a member of the miR-15 fa

SUBMITTER: Porrello ER 

PROVIDER: S-EPMC3167208 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature