Impairment of speech production predicted by lesion load of the left arcuate fasciculus.

ABSTRACT:

Background and purpose

Previous studies have suggested that patients' potential for poststroke language recovery is related to lesion size; however, lesion location may also be of importance, particularly when fiber tracts that are critical to the sensorimotor mapping of sounds for articulation (eg, the arcuate fasciculus) have been damaged. In this study, we tested the hypothesis that lesion loads of the arcuate fasciculus (ie, volume of arcuate fasciculus that is affected by a patient's lesion) and of 2 other tracts involved in language processing (the extreme capsule and the uncinate fasciculus) are inversely related to the severity of speech production impairments in patients with stroke with aphasia.

Methods

Thirty patients with chronic stroke with residual impairments

SUBMITTER: Marchina S 

PROVIDER: S-EPMC3167233 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature