Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder.

ABSTRACT:

Objective

Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal-striatal-thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal cortex) follow unique maturational trajectories, and altered connectivity within distinct loops may be differentially associated with OCD at specific stages of development.

Method

Altered development of striatal and thalamic connectivity to medial frontal cortex was tested in 60 OCD patients compared with 61 healthy control subjects at child, adolescent, and adult stages of development, using resting-state functional connectivity MRI.<

SUBMITTER: Fitzgerald KD 

PROVIDER: S-EPMC3167379 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature