Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men.

ABSTRACT:

Context

Glucose intake is associated with a variable increase in adrenal glucocorticoid secretion.

Hypothesis

Glucose ingestion elevates cortisol secretion by 1) augmenting pulsatile ACTH release; and/or 2) enhancing ACTH-cortisol synchrony or dose-responsiveness.

Subjects

Fifty-eight healthy men ages 19-78 yr with computed tomography-estimated abdominal visceral fat participated in the study.

Location

The study was conducted at the Clinical Translational-Research Center and Veterans Affairs Medical Center.

Methods

We conducted frequent sampling of plasma ACTH and cortisol concentrations after glucose vs. water ingestion in the fasting state, as well as deconvolution, approximate entropy, linear-regression, and dose-response analysis.

Outcomes

Aft

SUBMITTER: Iranmanesh A 

PROVIDER: S-EPMC3167666 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature