The economics of improving medication adherence in osteoporosis: validation and application of a simulation model.

ABSTRACT:

Context

Adherence to osteoporosis treatment is low. Although new therapies and behavioral interventions may improve medication adherence, questions are likely to arise regarding their cost-effectiveness.

Objective

Our objectives were to develop and validate a model to simulate the clinical outcomes and costs arising from various osteoporosis medication adherence patterns among women initiating bisphosphonate treatment and to estimate the cost-effectiveness of a hypothetical intervention to improve medication adherence.

Design

We constructed a computer simulation using estimates of fracture rates, bisphosphonate treatment effects, costs, and utilities for health states drawn from the published literature. Probabilities of transitioning on and off treatment were estimat

SUBMITTER: Patrick AR 

PROVIDER: S-EPMC3167669 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature