Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study.

ABSTRACT:

Context

Many factors influence the concentration of circulating testosterone and its primary binding protein, SHBG. However, little is known about the genetic contribution to their circulating concentrations in women, and their heritability in women is not well established.

Objective

Our objective was to estimate the heritability of circulating total testosterone (TT), free testosterone (FT), and SHBG in women in families from the Framingham Heart Study.

Methods

Women in the Framingham Heart Study who were not pregnant, had not undergone bilateral oophorectomy, and were not using exogenous hormones were eligible for this investigation. TT was measured using liquid chromatography tandem mass spectrometry and SHBG using an immunofluorometric assay (Delfia-Wallac), and F

SUBMITTER: Coviello AD 

PROVIDER: S-EPMC3167671 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature