Evolutionary versatility of eukaryotic protein domains revealed by their bigram networks.

ABSTRACT:

Background

Protein domains are globular structures of independently folded polypeptides that exert catalytic or binding activities. Their sequences are recognized as evolutionary units that, through genome recombination, constitute protein repertoires of linkage patterns. Via mutations, domains acquire modified functions that contribute to the fitness of cells and organisms. Recent studies have addressed the evolutionary selection that may have shaped the functions of individual domains and the emergence of particular domain combinations, which led to new cellular functions in multi-cellular animals. This study focuses on modeling domain linkage globally and investigates evolutionary implications that may be revealed by novel computational analysis.

Results

A survey of 77 co

SUBMITTER: Xie X 

PROVIDER: S-EPMC3167776 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature