Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development.

ABSTRACT:

Background

Factor H binding protein (fHbp) is an important antigen for vaccines against meningococcal serogroup B disease. The protein binds human factor H (fH), which enables the bacteria to resist serum bactericidal activity. Little is known about the vaccine-potential of fHbp for control of meningococcal epidemics in Africa, which typically are caused by non-group B strains.

Methodology/principal findings

We investigated genes encoding fHbp in 106 serogroup A, W-135 and X case isolates from 17 African countries. We determined complement-mediated bactericidal activity of antisera from mice immunized with recombinant fHbp vaccines, or a prototype native outer membrane vesicle (NOMV) vaccine from a serogroup B mutant strain with over-expressed fHbp. Eighty-six of the isolate

SUBMITTER: Pajon R 

PROVIDER: S-EPMC3167780 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature