Oral delivery of the Sj23LHD-GST antigen by Salmonella typhimurium type III secretion system protects against Schistosoma japonicum infection in mice.

ABSTRACT:

Background

Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders the presentation of expressed heterologous antigens to the major histocompatibility complex (MHC) molecules. The present work used an attenuated Salmonella typhimurium strain VNP20009 to secretory expression of Sj23LHDGST bivalent antigen from Schistosoma japonicum and tested the protective efficacy against S. japonicum infection in orally immunized mice.

Methodology/principal findings

Promoters (nirB or pagC) were used to express the antigen (Sj23LHDGST) and the

SUBMITTER: Chen G 

PROVIDER: S-EPMC3167783 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature