Disease gene interaction pathways: a potential framework for how disease genes associate by disease-risk modules.

ABSTRACT:

Background

Disease genes that interact cooperatively play crucial roles in the process of complex diseases, yet how to analyze and represent their associations is still an open problem. Traditional methods have failed to represent direct biological evidences that disease genes associate with each other in the pathogenesis of complex diseases. Molecular networks, assumed as 'a form of biological systems', consist of a set of interacting biological modules (functional modules or pathways) and this notion could provide a promising insight into deciphering this topic.

Methodology/principal findings

In this paper, we hypothesized that disease genes might associate by virtue of the associations between biological modules in molecular networks. Then we introduced a novel disease ge

SUBMITTER: Chen L 

PROVIDER: S-EPMC3167857 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature