Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

ABSTRACT: Schizosaccharomyces pombe cells have a well-defined pattern of polarized growth at the cell ends during interphase and divide symmetrically into two equal-sized daughter cells. We identified a gene, pom1, that provides positional information for both growth and division in S. pombe. pom1 mutants form functioning growth zones and division septa but show several abnormalities: (1) After division, cells initiate growth with equal frequencies from either the old or the new end; (2) most cells never switch to bipolar growth but instead grow exclusively at the randomly chosen end; (3) some cells mislocalize their growth axis altogether, leading to the formation of angled and branched cells; and (4) many cells misplace and/or misorient their septa, leading to asymmetric cell division. pom1 encode

SUBMITTER: Bahler J 

PROVIDER: S-EPMC316787 | biostudies-literature | 1998 May

REPOSITORIES: biostudies-literature