Host transcription factors in the immediate pro-inflammatory response to the parasitic mite Psoroptes ovis.

ABSTRACT:

Background

Sheep scab, caused by infestation with the ectoparasitic mite Psoroptes ovis, results in the rapid development of cutaneous inflammation and leads to the crusted skin lesions characteristic of the disease. We described previously the global host transcriptional response to infestation with P. ovis, elucidating elements of the inflammatory processes which lead to the development of a rapid and profound immune response. However, the mechanisms by which this response is instigated remain unclear. To identify novel methods of intervention a better understanding of the early events involved in triggering the immune response is essential. The objective of this study was to gain a clearer understanding of the mechanisms and signaling pathways involved in the instigation of the

SUBMITTER: Burgess ST 

PROVIDER: S-EPMC3168495 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature