Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation.

ABSTRACT: High risk human papillomaviruses are squamous epitheliotropic viruses that may cause cervical and other cancers. HPV replication depends on squamous epithelial differentiation. Transformation of HPV-infected cells goes along with substantial alteration of the viral gene expression profile and preferentially occurs at transformation zones usually at the uterine cervix. Methylation of the viral genome may affect regulatory features that control transcription and replication of the viral genome. Therefore, we analyzed the methylation pattern of the HPV16 upstream regulatory region (URR) during squamous epithelial differentiation and neoplastic transformation and analyzed how shifts in the HPV URR methylome may affect viral gene expression and replication. HPV 16 positive biopsy sections encom

SUBMITTER: Vinokurova S 

PROVIDER: S-EPMC3168499 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature