Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?

ABSTRACT:

Objective

To examine further the relationship between diabetes mellitus (DM), genotype and prostate cancer aggressiveness. Specifically, we sought to evaluate for effect modification between DM, a newly discovered prostate cancer susceptibility locus on chromosome 17q12 (single nucleotide polymorphism rs4430796) and prostate cancer features.

Patients and methods

In 593 genotyped men treated with radical prostatectomy (RP), we examined RP features stratified by DM and rs4430796 carrier status.

Results

Despite a significantly higher body mass index among patients with DM, individual pathological features were similar between men with and without DM. Using a dominant model, 17q12 carriers were less likely to have DM and more likely to have a RP Gleason score of >or=7. Ho

SUBMITTER: Loeb S 

PROVIDER: S-EPMC3168555 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature