Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization.

ABSTRACT:

Objective

To investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation.

Design

Fasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking.

Setting

A reproductive health center.

Patient(s)

Forty-four women undergoing IVF.

Intervention(s)

None.

Main outcome measure(s)

Peak E(2) level and the number of oocytes retrieved du

SUBMITTER: Bloom MS 

PROVIDER: S-EPMC3168558 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature