Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder.

ABSTRACT: Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridization on 113

SUBMITTER: Vu TH 

PROVIDER: S-EPMC3168586 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature