Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study.

ABSTRACT: Progressive supranuclear palsy (PSP) is associated with pathological changes along the dentatorubrothalamic tract and in premotor cortex. We aimed to assess whether functional neural connectivity is disrupted along this pathway in PSP, and to determine how functional changes relate to changes in structure and diffusion. Eighteen probable PSP subjects and 18 controls had resting-state (task-free) fMRI, diffusion tensor imaging and structural MRI. Functional connectivity was assessed between thalamus and the rest of the brain, and within the basal ganglia, salience and default mode networks (DMN). Patterns of atrophy were assessed using voxel-based morphometry, and patterns of white matter tract degeneration were assessed using tract-based spatial statistics. Reduced in-phase functional conn

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3168952 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature