Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair.

ABSTRACT: Transcription factors that play a role in ossification during development are expected to participate in postnatal fracture repair since the endochondral bone formation that occurs in embryos is recapitulated during fracture repair. However, inherent differences exist between bone development and fracture repair, including a sudden disruption of tissue integrity followed by an inflammatory response. This raises the possibility that repair-specific transcription factors participate in bone healing. Here, we assessed the consequence of loss of early growth response gene 1 (EGR-1) on endochondral bone healing because this transcription factor has been shown to modulate repair in vascularized tissues. Model fractures were created in ribs of wild type (wt) and EGR-1(-/-) mice. Differences in ti

SUBMITTER: Reumann MK 

PROVIDER: S-EPMC3169183 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature