Ontology highlight
ABSTRACT:
SUBMITTER: Wei G
PROVIDER: S-EPMC3169184 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Immunity 20110801 2
The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation. To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding sites in ten well-defined developmental and effector T lymphocyte lineages. In the thymus, GATA3 directly regulated many critical factors, including Th-POK, Notch1, and T cell receptor subunits. In the periphery, GATA3 induced a large number of Th2 cell-specific as well as Th2 cell-nonspec ...[more]