Global organization of protein complexome in the yeast Saccharomyces cerevisiae.

ABSTRACT:

Background

Proteins in organisms, rather than act alone, usually form protein complexes to perform cellular functions. We analyze the topological network structure of protein complexes and their component proteins in the budding yeast in terms of the bipartite network and its projections, where the complexes and proteins are its two distinct components. Compared to conventional protein-protein interaction networks, the networks from the protein complexes show more homogeneous structures than those of the binary protein interactions, implying the formation of complexes that cause a relatively more uniform number of interaction partners. In addition, we suggest a new optimization method to determine the abundance and function of protein complexes, based on the information of their gl

SUBMITTER: Lee SH 

PROVIDER: S-EPMC3169507 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature