IPNV with high and low virulence: host immune responses and viral mutations during infection.

ABSTRACT:

Background

Infectious pancreatic necrosis virus (IPNV) is an aquatic member of the Birnaviridae family that causes widespread disease in salmonids. IPNV is represented by multiple strains with markedly different virulence. Comparison of isolates reveals hyper variable regions (HVR), which are presumably associated with pathogenicity. However little is known about the rates and modes of sequence divergence and molecular mechanisms that determine virulence. Also how the host response may influence IPNV virulence is poorly described.

Methods

In this study we compared two field isolates of IPNV (NFH-Ar and NFH-El). The sequence changes, replication and mortality were assessed following experimental challenge of Atlantic salmon. Gene expression analyses with qPCR and microarray w

SUBMITTER: Skjesol A 

PROVIDER: S-EPMC3169513 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature