Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

ABSTRACT: Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome system (UPS). Previous studies have described an age-dependent decline of proteasomal function and increased longevity correlates with sustained proteasome capacity in centenarians and in naked mole rats, a long-lived rodent. Proof for a direct impact of enhanced proteasome function on longevity, however, is still lacking. To determine the importance of proteasome function in yeast aging, we established a method to modulate UPS capacity by manipulating levels of the UPS-related transcription factor Rpn4. While cells lacking RPN4 exhibit a decreased

SUBMITTER: Kruegel U 

PROVIDER: S-EPMC3169524 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature