Transcription analysis on response of swine lung to H1N1 swine influenza virus.

ABSTRACT:

Background

As a mild, highly contagious, respiratory disease, swine influenza always damages the innate immune systems, and increases susceptibility to secondary infections which results in considerable morbidity and mortality in pigs. Nevertheless, the systematical host response of pigs to swine influenza virus infection remains largely unknown. To explore it, a time-course gene expression profiling was performed for comprehensive analysis of the global host response induced by H1N1 swine influenza virus in pigs.

Results

At the early stage of H1N1 swine virus infection, pigs were suffering mild respiratory symptoms and pathological changes. A total of 268 porcine genes showing differential expression (DE) after inoculation were identified to compare with the controls on day

SUBMITTER: Li Y 

PROVIDER: S-EPMC3169531 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature