Defining the molecular character of the developing and adult kidney podocyte.

ABSTRACT:

Background

The podocyte is a remarkable cell type, which encases the capillaries of the kidney glomerulus. Although mesodermal in origin it sends out axonal like projections that wrap around the capillaries. These extend yet finer projections, the foot processes, which interdigitate, leaving between them the slit diaphragms, through which the glomerular filtrate must pass. The podocytes are a subject of keen interest because of their key roles in kidney development and disease.

Methodology/principal findings

In this report we identified and characterized a novel transgenic mouse line, MafB-GFP, which specifically marked the kidney podocytes from a very early stage of development. These mice were then used to facilitate the fluorescent activated cell sorting based purificatio

SUBMITTER: Brunskill EW 

PROVIDER: S-EPMC3169617 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature