Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

ABSTRACT:

Background

Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4), variations in infection are common within both R5- and X4-tropic viruses, indicating additional factors may contribute to viral tropism.

Methodology and principal findings

Using both solution and cell surface binding experiments, we showed that R5- and X4-tropic HIV-1 gp120 proteins recognized a family of I-type lectin receptors, the Sialic acid-binding immunoglobulin-like lectins (Siglec). The recognition was through envelope-associated sialic acids that promoted viral adhesion to macrophages. The sialic acid-mediated vira

SUBMITTER: Zou Z 

PROVIDER: S-EPMC3169630 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature