The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.

ABSTRACT: The tissue polarity mutants in Drosophila include a set of conserved gene products that appear to be involved in the control of cytoskeletal architecture. Here we show that the tissue polarity gene prickle (pk) encodes a protein with a triple LIM domain and a novel domain that is present in human, murine, and Caenorhabditis elegans homologs which we designate PET. Three transcripts have been identified, pk, pkM, and sple, encoding 93-, 100-, and 129-kD conceptual proteins, respectively. The three transcripts span 70 kb and share 6 exons that contain the conserved domains. The pk and sple transcripts are expressed with similar tissue-specific patterns but have qualitatively different activities. The phenotypes of pk mutants, and transgenic flies in which the different isoforms are overexpre

SUBMITTER: Gubb D 

PROVIDER: S-EPMC316995 | biostudies-literature | 1999 Sep

REPOSITORIES: biostudies-literature