Cost-effectiveness of early responders versus early nonresponders to atypical antipsychotic therapy.

ABSTRACT:

Background

To compare the cost-effectiveness of treating early responders versus early nonresponders to an atypical antipsychotic (risperidone) and the cost-effectiveness of treating early nonresponders maintained on risperidone versus those switched to olanzapine.

Methods

This post hoc analysis used data from a randomized, double-blind, 12-week schizophrenia study (Study Code: HGMN, n = 628). Participants were initially assigned to risperidone therapy. Early response was defined as a ≥ 20% improvement on the Positive and Negative Syndrome Scale (PANSS) total score from baseline to two weeks. Early responders continued on risperidone, whereas early nonresponders were randomized in a double-blind manner to continue on risperidone or switch to olanzapine for 10 additional week

SUBMITTER: Peng X 

PROVIDER: S-EPMC3169978 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature