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Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

ABSTRACT:

Purpose

To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.

Methods

Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.

Results

The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).

Conclusion

The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

SUBMITTER: Miyamoto T

PROVIDER: S-EPMC3170112 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

Miyamoto Toshinobu T Tsujimura Akira A Miyagawa Yasushi Y Koh Eitetsu E Namiki Mikio M Horikawa Michiharu M Saijo Yasuaki Y Sengoku Kazuo K

Journal of assisted reproduction and genetics 20110504 8

<h4>Purpose</h4>To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.<h4>Methods</h4>Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.<h4>Results</h4>The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).<h4>Conclusion</h4>The c.1,066A>T variant in the UBR2 gene is associated with incr ...[more]

PMID: 21573678

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