Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy.

ABSTRACT:

Introduction

The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP). There is an urgent need to identify safe, well-tolerated and efficacious alternatives to SP due to widespread Plasmodium falciparum resistance. Combination therapy using azithromycin and chloroquine is one possibility that has demonstrated adequate parasitological response > 95% in clinical trials of non-pregnant adults in sub-Saharan Africa and where IPTp is a government policy in 33 countries.

Areas covered

Key safety, tolerability and efficacy data are presented for azithromycin and chloroquine, alone and/or in combination, when used to prevent and/or treat P. falciparum, P. vivax, and several curable sexually transmitted and rep

SUBMITTER: Chico RM 

PROVIDER: S-EPMC3170143 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature