Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.

ABSTRACT: Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.

SUBMITTER: Wu J 

PROVIDER: S-EPMC3170163 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature