Unknown

Dataset Information

0

Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with ?-ketones.

ABSTRACT: The gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation reaction offers a simple and efficient method for the synthesis of pyrrolidine derivatives in moderate to excellent product yields and with moderate to good diastereoselectivities. The reaction conditions and the substrate scope of this reaction are examined, and a possible mechanism involving AgClO(4) catalyzed intermolecular N-Michael addition and the subsequent gold(I)-catalyzed hydroalkylation is proposed.

SUBMITTER: Xiao YP 

PROVIDER: S-EPMC3170194 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with α-ketones.

Xiao Ya-Ping YP   Liu Xin-Yuan XY   Che Chi-Ming CM  

Beilstein journal of organic chemistry 20110811

The gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation reaction offers a simple and efficient method for the synthesis of pyrrolidine derivatives in moderate to excellent product yields and with moderate to good diastereoselectivities. The reaction conditions and the substrate scope of this reaction are examined, and a possible mechanism involving AgClO(4) catalyzed intermolecular N-Michael addition and the subsequent gold(I)-catalyzed hydroalk  ...[more]

Similar Datasets

Unknown Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes.
| S-EPMC6054511 | biostudies-literature
Unknown Alkylgold complexes by the intramolecular aminoauration of unactivated alkenes.
| S-EPMC3866133 | biostudies-literature
Unknown Catalytic intramolecular aminoarylation of unactivated alkenes with aryl sulfonamides.
| S-EPMC9200115 | biostudies-literature
Unknown Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes.
| S-EPMC6488029 | biostudies-literature
Unknown Carboamination of Unactivated Alkenes through Three-Component Radical Conjugate Addition.
| S-EPMC6900080 | biostudies-literature
Unknown Enantioselective, Aerobic Copper-Catalyzed Intramolecular Carboamination and Carboetherification of Unactivated Alkenes.
| S-EPMC8293922 | biostudies-literature
Unknown Intermolecular oxidative amination of unactivated alkenes by dual photoredox and copper catalysis.
| S-EPMC8179295 | biostudies-literature
Unknown Synergistic palladium/enamine catalysis for asymmetric hydrocarbon functionalization of unactivated alkenes with ketones.
| S-EPMC6677245 | biostudies-literature
Unknown Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives.
| S-EPMC4077384 | biostudies-literature
Unknown Bifunctional Iminophosphorane-Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides.
| S-EPMC8793149 | biostudies-literature