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Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling.

ABSTRACT: The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen-lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2), in under a minute.

SUBMITTER: Nagaki A

PROVIDER: S-EPMC3170206 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling.

Nagaki Aiichiro A Uesugi Yuki Y Tomida Yutaka Y Yoshida Jun-Ichi J

Beilstein journal of organic chemistry 20110802

The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen-lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2), in under a minute. ...[more]

PMID: 21915209

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