TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients.

ABSTRACT:

Background

Single-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma.

Methods

Genotype distribution of TP53 codon 72 and MDM2 SNP309 in 61 viral hepatitis-related hepatocellular carcinoma cases and 122 blood samples (healthy controls) from Italian subjects were determined by PCR and restriction fragment length polymorphism (RFLP).

Results

Frequencies of TP53 codon 72 alleles were not significantly different between cases and controls. A significant increase of MDM2 SNP309 G/G and T/G genotype

SUBMITTER: Di Vuolo V 

PROVIDER: S-EPMC3170208 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature