Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus.

ABSTRACT: The increasing antibiotic resistance in bacterial populations requires alternatives for classical treatment of infectious diseases and therefore drives the renewed interest in phage therapy. Methicillin resistant Staphylococcus aureus (MRSA) is a major problem in health care settings and live-stock breeding across the world. This research aims at a thorough microbiological, genomic, and proteomic characterization of S. aureus phage ISP, required for therapeutic applications. Host range screening of a large batch of S. aureus isolates and subsequent fingerprint and DNA microarray analysis of the isolates revealed a substantial activity of ISP against 86% of the isolates, including relevant MRSA strains. From a phage therapy perspective, the infection parameters and the frequency of bacteria

SUBMITTER: Vandersteegen K 

PROVIDER: S-EPMC3170307 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature