Tight associations between transcription promoter type and epigenetic variation in histone positioning and modification.

ABSTRACT:

Background

Transcription promoters are fundamental genomic cis-elements controlling gene expression. They can be classified into two types by the degree of imprecision of their transcription start sites: peak promoters, which initiate transcription from a narrow genomic region; and broad promoters, which initiate transcription from a wide-ranging region. Eukaryotic transcription initiation is suggested to be associated with the genomic positions and modifications of nucleosomes. For instance, it has been recently shown that histone with H3K9 acetylation (H3K9ac) is more likely to be distributed around broad promoters rather than peak promoters; it can thus be inferred that there is an association between histone H3K9 and promoter architecture.

Results

Here, we performed a sy

SUBMITTER: Nozaki T 

PROVIDER: S-EPMC3170308 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature