Growth-arrest-specific protein 2 inhibits cell division in Xenopus embryos.

ABSTRACT:

Background

Growth-arrest-specific 2 gene was originally identified in murine fibroblasts under growth arrest conditions. Furthermore, serum stimulation of quiescent, non-dividing cells leads to the down-regulation of gas2 and results in re-entry into the cell cycle. Cytoskeleton rearrangements are critical for cell cycle progression and cell division and the Gas2 protein has been shown to co-localize with actin and microtubules in interphase mammalian cells. Despite these findings, direct evidence supporting a role for Gas2 in the mechanism of cell division has not been reported.

Methodology and principal findings

To determine whether the Gas2 protein plays a role in cell division, we over-expressed the full-length Gas2 protein and Gas2 truncations containing either the acti

SUBMITTER: Zhang T 

PROVIDER: S-EPMC3170402 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature