Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease.

ABSTRACT:

Objective

Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public has led to its frequent consideration in the differential diagnosis of patients with rapidly progressive dementia (RPD). Our goal was to determine which treatable disorders are most commonly mistaken for CJD.

Methods

We performed a retrospective clinical and neuropathological review of prion-negative brain autopsy cases referred to the US National Prion Disease Pathology Surveillance Center at Case Western Reserve University from January 2006 through December 2009.

Results

Of 1,106 brain autopsies, 352 (32%) were negative for prion disease, 304 of which had adequate tissue for histopathological analysis. Alzheimer disease (n = 154) and vascular dementia (n = 36) were

SUBMITTER: Chitravas N 

PROVIDER: S-EPMC3170496 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature