Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury.

ABSTRACT:

Objective

Although magnetic resonance imaging (MRI) is the optimal imaging modality to define cerebral white-matter injury (WMI) in preterm survivors, the histopathological features of MRI-defined chronic lesions are poorly defined. We hypothesized that chronic WMI is related to a combination of delayed oligodendrocyte (OL) lineage cell death and arrested maturation of preoligodendrocytes (preOLs). We determined whether ex vivo MRI can distinguish distinct microglial and astroglial responses related to WMI progression and arrested preOL differentiation.

Methods

We employed a preterm fetal sheep model of global cerebral ischemia in which acute WMI results in selective preOL degeneration. We developed novel algorithms to register histopathologically-defined lesions with contra

SUBMITTER: Riddle A 

PROVIDER: S-EPMC3170499 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature