Short term efficacy of nebulized beclomethasone in mild-to-moderate wheezing episodes in pre-school children.

ABSTRACT:

Background

Few data are available on the usefulness of short term treatment with low-medium dose of inhaled corticosteroids (ICS) in pre-school children with wheezing exacerbations.

Methods

To compare the efficacy of one week treatment with 400 μg b.i.d. nebulized beclomethasone dipropionate (BDP), plus nebulized 2500 μg prn salbutamol (BDP group), versus nebulized b.i.d. placebo, plus nebulized prn 2500 μg salbutamol (placebo group), a post-hoc analysis was performed on data obtained in 166 pre-school children with multiple-trigger wheezing, recruited during an acute wheezing episode.

Results

The percentage of symptom-free days (SFDs) was significantly higher in the BDP group (54.7%) than in the placebo group (40.5%; p = 0.012), with a 35% relative difference. Day-by

SUBMITTER: Papi A 

PROVIDER: S-EPMC3170583 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature