Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity.

ABSTRACT: We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

SUBMITTER: Tong S 

PROVIDER: S-EPMC3170660 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature