Evidence for network evolution in an Arabidopsis interactome map.

ABSTRACT: Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant intera

SUBMITTER: Arabidopsis Interactome Mapping Consortium 

PROVIDER: S-EPMC3170756 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature