Association study of Wnt signaling pathway genes in bipolar disorder.

ABSTRACT:

Context

The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder.

Objective

To test for an association between candidate genes in the Wnt signaling pathways and disease susceptibility in a family-based bipolar disorder study.

Design

Two hundred twenty-seven tagging single- nucleotide polymorphisms (SNPs) from 34 genes were successfully genotyped. Initial results led us to focus on the gene PPARD, in which we genotyped an additional 13 SNPs for follow-up.

Setting

Nine academic medical centers in the United States.

Participants

Five hundred fifty-four offspring with bipolar disorder and their parents from 317

SUBMITTER: Zandi PP 

PROVIDER: S-EPMC3170992 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature