The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis.

ABSTRACT: Coordination between adjacent tissues plays a crucial role during the morphogenesis of developing organs. In the embryonic heart, two tissues - the myocardium and the endocardium - are closely juxtaposed throughout their development. Myocardial and endocardial cells originate in neighboring regions of the lateral mesoderm, migrate medially in a synchronized fashion, collaborate to create concentric layers of the heart tube, and communicate during formation of the atrioventricular canal. Here, we identify a novel transmembrane protein, Tmem2, that has important functions during both myocardial and endocardial morphogenesis. We find that the zebrafish mutation frozen ventricle (frv) causes ectopic atrioventricular canal characteristics in the ventricular myocardium and endocardium, indicatin

SUBMITTER: Totong R 

PROVIDER: S-EPMC3171221 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature