Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice.

ABSTRACT:

Background

Obesity-related adipose inflammation has been thought to be a causal factor for the development of insulin resistance and type 2 diabetes. Infiltrated macrophages in adipose tissue of obese animals and humans are an important source for inflammatory cytokines. Clodronate liposomes can ablate macrophages by inducing apoptosis. In this study, we aim to determine whether peritoneal injection of clodronate liposomes has any beneficial effect on systemic glucose homeostasis/insulin sensitivity and whether macrophage content in visceral adipose tissue will be reduced in diet-induced obese (DIO) mice.

Methodology/principal findings

Clodronate liposomes were used to deplete macrophages in lean and DIO mice. Macrophage content in visceral adipose tissue, metabolic paramete

SUBMITTER: Feng B 

PROVIDER: S-EPMC3171445 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature