Major intrinsic protein (MIP) polymorphism is associated with age-related cataract in Chinese.

ABSTRACT:

Purpose

Age-related cataract (ARC) is a complex multi-factorial disorder involving several genetic and environmental factors. The major intrinsic protein of lens fiber gene (MIP) encodes the most abundant junctional membrane protein in the mature lens and plays a critical role in maintainace of lens normal structure and internal circulation. To determine the relationship between single nucleotide polymorphisms (SNPs) in MIP and the susceptibility to ARC in a Chinese population, we conducted this case-control study.

Methods

A total of 164 unrelated ARC patients and 132 normal controls were involved in the study. All participants completed full physical and ophthalmic examinations and provided a blood sample for DNA extraction. Seven SNPs (rs2269348, rs61759527, c.-4T>C, rs771

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC3171496 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature