Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population.

ABSTRACT:

Purpose

To evaluate the association of Toll-like receptor 4 (TLR4) gene polymorphisms with normal tension glaucoma (NTG) in the South Korean population.

Methods

A total of 147 normal tension glaucoma patients in South Korea were recruited from April, 2007 to August, 2008. Allele, genotype, and haplotype of 8 different types of TLR4 single nucleotide polymorphisms were analyzed: rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, and rs7045953. Three hundred eighty healthy, unrelated South Korean adults were enrolled as controls.

Results

Frequencies of the TLR4 allele did not show any statistically significant difference between normal tension glaucoma patients and the control group (p>0.00625). The same results were observed in genotype fre

SUBMITTER: Suh W 

PROVIDER: S-EPMC3171501 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature