Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing.

ABSTRACT: Quorum sensing (QS) is a population-dependent signaling process bacteria use to control multiple processes including virulence that is critical for establishing infection. The most common QS signaling molecule used by Gram-negative bacteria are acylhomoserine lactones. The development of non-native acylhomoserine lactone (AHL) ligands has emerged as a promising new strategy to inhibit QS in Gram-negative bacteria. In this work, we have synthesized a set of optically pure γ-lactams and their reduced cyclic azahemiacetal analogues, bearing the additional alkylthiomethyl substituent, and evaluated their effect on the AHL-dependent Pseudomonas aeruginosa las and rhl QS pathways. The concentration of these ligands and the simple structural modification such as the length of the alkylthio substi

SUBMITTER: Malladi VL 

PROVIDER: S-EPMC3171587 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature