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An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate.

ABSTRACT: Aryl thioamides undergo a very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency.

SUBMITTER: Mayhoub AS

PROVIDER: S-EPMC3171967 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate.

Mayhoub Abdelrahman S AS Kiselev Evgeny E Cushman Mark M

Tetrahedron letters 20110901 38

Aryl thioamides undergo a very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency. ...[more]

PMID: 21927513

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